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DNA methylation-based prediction of response to immune checkpoint inhibition in metastatic melanoma

1 Jul 2021

Abstract excerpt

BACKGROUND: Therapies based on targeting immune checkpoints have revolutionized the treatment of metastatic melanoma in recent years. Still, biomarkers predicting long-term therapy responses are lacking. METHODS: A novel approach of reference-free deconvolution of large-scale DNA methylation data enabled us to develop a machine learning classifier based on CpG sites, specific for latent methylation components...

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PMID: 34281986
DOI: 10.1136/jitc-2020-002226

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