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Article

Genetic variability of the prion protein gene (PRNP) in thin-tailed and fat-tailed sheep.

Open veterinary journal - 1 Jun 2025

Wicaksono Arif, Haryanto Aris, Ibrahim Alek, Suryandari Anggita, Puspita Rana Ayuningtyas Adhi, Purwaningrum Medania

Abstract excerpt

Background: Scrapie is a deadly neurodegenerative transmissible spongiform encephalopathy (TSE) that affects sheep and goats. TSEs are a consequence of polymorphisms of the prion protein gene PRNP, which result in misfolded prion proteins. They are transmitted through contact with the abnormal proteins (prions). Currently, there are no data regarding the identification of PRNP variability in Indonesian sheep...

Read the complete abstract on PubMed

Topics

Animals
Scrapie
Sheep
Prion Proteins
Genetic Variation
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genotype

Indonesia

Source

Open in PubMed Open full text

Identifiers

PMID: 40989602
DOI: 10.5455/OVJ.2025.v15.i6.47
PMCID: PMC12451116

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

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