Article
The complement C7 variant rs3792646 is associated with amyotrophic lateral sclerosis in a Han Chinese population.
Neurobiology of aging - 1 Mar 2021
He Ji, Fu Jiayu, Fan Dongsheng
Abstract excerpt
The complement system has been shown to have a critical pathogenetic role in amyotrophic lateral sclerosis (ALS). Recently a C7 variant in rs3792646 was linked to neurodegenerative diseases in a Chinese population. We used whole exome sequencing to evaluate the role of C7 (rs3792646) in ALS in a Chinese cohort with 1970 individuals. The minor allele frequency in cases was 0.032 while 0.016 in controls, suggesting...
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