Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Monomerization of Homodimeric Trefoil Factor 3 (TFF3) by an Aminonitrile Compound Inhibits TFF3-Dependent Cancer Cell Survival

17 Aug 2022

Abstract excerpt

Trefoil factor 3 (TFF3) is a secreted protein with an established oncogenic function and a highly significant association with clinical progression of various human malignancies. Herein, a novel small molecule that specifically targets TFF3 homodimeric functions was identified. Utilizing the concept of reversible covalent interaction, 2-amino-4-(4-(6-fluoro-5-methylpyridin-3-yl)phenyl)-5-oxo-4H,5H-pyrano[3,2- c...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Chronic Lymphocytic Leukemia Research
Share to Monoclonal and Polyclonal Antibodies Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36110371
DOI: 10.1021/acsptsci.2c00044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Monomerization of Homodimeric Trefoil Factor 3 (TFF3) by an Aminonitrile Compound Inhibits TFF3-Dependent Cancer Cell SurvivalPMID 36110371Read ↗

Expression of two non-mutated genetic elements is sufficient to stimulate oncogenic transformation of human mammary epithelial cellsSemantic proximity Read ↗

Highly Specific Cytokine Receptor-Targeting Chimeras for Targeted Membrane Protein Degradation and Sensitization of Osimertinib in EGFR-Mutated Non-Small-Cell Lung Cancer.Semantic proximity Read ↗

Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders.Semantic proximity Read ↗

Targeting the Undruggable: Recent Progress in PROTAC-Induced Transcription Factor DegradationSemantic proximity Read ↗

A Selective FGFR1/2 PROTAC Degrader with Antitumor ActivitySemantic proximity Read ↗

Cooperative stabilisation of 14-3-3σ protein–protein interactions via covalent protein modificationSemantic proximity Read ↗

Development of folate receptor targeting chimeras for cancer selective degradation of extracellular proteinsSemantic proximity Read ↗

FAM83 proteins: Fostering new interactions to drive oncogenic signaling and therapeutic resistanceSemantic proximity Read ↗

Steroid receptor coactivator-3 as a potential molecular target for cancer therapySemantic proximity Read ↗

A BPTF-specific PROTAC degrader enhances NK cell-based cancer immunotherapySemantic proximity Read ↗

BPC-157 Predicted to Bind SH3 Domains and Activate Src Family Kinases: In Silico Modeling and Fluorescent Fusion Protein ValidationSemantic proximity Read ↗

Trefoil factor 3 mediation of oncogenicity and chemoresistance in hepatocellular carcinoma is AKT-BCL-2 dependentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.