The association between overweight and varying degrees of obesity with subjective well-being and depressive symptoms: A two sample Mendelian randomization study.

Abstract excerpt

OBJECTIVE: This study utilized the Mendelian randomization (MR) method to elucidate the causal relationship between genetically predicted overweight and various degrees of obesity with depressive symptoms and subjective well-being (SWB). METHODS: Pooled genome-wide association studies (GWAS) data for overweight (BMI ≥ 25 kg/m2), class 1 obesity (BMI ≥ 30 kg/m2), and class 2 obesity (BMI ≥ 35 kg/m2) were used as...

Topics

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• Body Mass Index
• Depression
• Genome-Wide Association Study
• Mendelian Randomization Analysis
• Obesity