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Article

Somatic mutations in benign breast disease tissues and association with breast cancer risk.

BMC medical genomics - 14 Jul 2021

Winham Stacey J, Wang Chen, Heinzen Ethan P, Bhagwate Aditya, Liu Yuanhang, McDonough Samantha J, Stallings-Mann Melody L, Frost Marlene H, Vierkant Robert A, Denison Lori A, Carter Jodi M, Sherman Mark E, Radisky Derek C, Degnim Amy C, Cunningham Julie M

Abstract excerpt

BACKGROUND: Benign breast disease (BBD) is a risk factor for breast cancer (BC); however, little is known about the genetic alterations present at the time of BBD diagnosis and how these relate to risk of incident BC. METHODS: A subset of a long-term BBD cohort was selected to examine DNA variation across three BBD groups (42 future estrogen receptor-positive (ER+) BC, 36 future estrogen receptor-negative (ER-)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34261476
DOI: 10.1186/s12920-021-01032-8
PMCID: PMC8278587

Genes

BRIP1
EXT2
GATA3
MED12
MLH1
MSH2
MUC16
PMS1
TGFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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