Article
Differential motor neuron impairment and axonal regeneration in sporadic and familiar amyotrophic lateral sclerosis with SOD-1 mutations: lessons from neurophysiology.
International journal of molecular sciences - 1 Jan 2011
Bocci Tommaso, Pecori Chiara, Giorli Elisa, Briscese Lucia, Tognazzi Silvia, Caleo Matteo, Sartucci Ferdinando
Abstract excerpt
UNLABELLED: Amyotrophic Lateral Sclerosis (ALS) is a degenerative disorder of the motor system. About 10% of cases are familial and 20% of these families have point mutations in the Cu/Zn superoxide dismutase 1 (SOD-1) gene. SOD-1 catalyses the superoxide radical (O(-2)) into hydrogen peroxide and molecular oxygen. The clinical neurophysiology in ALS plays a fundamental role in differential diagnosis between the...
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