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FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in <i>C9orf72</i> -linked ALS/FTD

2022-11-01

Abstract excerpt

Abnormal expansions of GGGGCC repeat sequence in the noncoding region of the C9orf72 gene is the most common cause of familial amyotrophic lateral sclerosis and frontotemporal dementia (C9-ALS/FTD). The expanded repeat sequence is translated into dipeptide repeat proteins (DPRs) by noncanonical repeat-associated non-AUG (RAN) translation. Since DPRs play central roles in the pathogenesis of C9-ALS/FTD, we here in...

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Literature Corpus work
60220776-b06e-525a-a466-62000895301c
DOI
10.1101/2022.11.01.514717
Open publication

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FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in <i>C9orf72</i> -linked ALS/FTDDOI 10.1101/2022.11.01.514717
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