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Article

Peroxiredoxin 1 Interacts with TBK1/IKKε and Negatively Regulates Pseudorabies Virus Propagation by Promoting Innate Immunity.

Journal of virology - 9 Sept 2021

Lv Lin, Bai Juan, Gao Yanni, Jin Ling, Wang Xianwei, Cao Mingzhu, Liu Xing, Jiang Ping

Abstract excerpt

Peroxiredoxin 1 (PRDX1) is a cellular antioxidant enzyme that is crucial for diverse fundamental biological processes, such as autophagy, inflammation, and carcinogenesis. However, molecular mechanisms underpinning its diverse roles are not well understood. Here, we report that PRDX1 positively regulates interferon (IFN) induction and that pseudorabies virus (PRV) targets PRDX1 to evade IFN induction. PRV UL13...

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Source

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Identifiers

PMID: 34260286
DOI: 10.1128/JVI.00923-21
PMCID: PMC8428385

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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