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Article

HDAC Inhibition Induces Cell Cycle Arrest and Mesenchymal-Epithelial Transition in a Novel Pleural-Effusion Derived Uterine Carcinosarcoma Cell Line.

Pathology oncology research : POR - 1 Jan 2021

Stockhammer Paul, Okumus Özlem, Hegedus Luca, Rittler Dominika, Ploenes Till, Herold Thomas, Kalbourtzis Stavros, Bankfalvi Agnes, Sucker Antje, Kimmig Rainer, Aigner Clemens, Hegedus Balazs

Abstract excerpt

Objective: Uterine carcinosarcoma (UCS) is a rare but highly aggressive malignancy with biphasic growth pattern. This morphology can be attributed to epithelial-mesenchymal transition (EMT) that often associates with tumor invasion and metastasis. Accordingly, we analyzed a novel patient-derived preclinical model to explore whether EMT is a potential target in UCS. Methods: A novel UCS cell line (PF338) was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34257602
DOI: 10.3389/pore.2021.636088
PMCID: PMC8262245

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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