Article
Neuroradiological, genetic and clinical characteristics of histone H3 K27-mutant diffuse midline gliomas in the Kansai Molecular Diagnosis Network for CNS Tumors (Kansai Network): multicenter retrospective cohort.
Acta neuropathologica communications - 27 Jul 2024
Hayashi Nobuhide, Fukai Junya, Nakatogawa Hirokazu, Kawaji Hiroshi, Yoshioka Ema, Kodama Yoshinori, Nakajo Kosuke, Uda Takehiro, Naito Kentaro, Kijima Noriyuki, Okita Yoshiko, Kagawa Naoki, Takahashi Yoshinobu, Hashimoto Naoya, Arita Hideyuki, Takano Koji, Sakamoto Daisuke, Iida Tomoko, Arakawa Yoshiki, Kawauchi Takeshi, Sonoda Yukihiko, Mitobe Yuta, Ishibashi Kenichi, Matsuda Masahide, Achiha Takamune, Tomita Takahiro, Nonaka Masahiro, Hara Keijiro, Takebe Noriyoshi, Tsuzuki Takashi, Nakajima Yoshikazu, Ohue Shiro, Nakajima Nobuyuki, Watanabe Akira, Inoue Akihiro, Umegaki Masao, Kanematsu Daisuke, Katsuma Asako, Sumida Miho, Shofuda Tomoko, Mano Masayuki, Kinoshita Manabu, Mori Kanji, Nakao Naoyuki, Kanemura Yonehiro
Abstract excerpt
This study aims to elucidate the clinical and molecular characteristics, treatment outcomes and prognostic factors of patients with histone H3 K27-mutant diffuse midline glioma. We retrospectively analyzed 93 patients with diffuse midline glioma (47 thalamus, 24 brainstem, 12 spinal cord and 10 other midline locations) treated at 24 affiliated hospitals in the Kansai Molecular Diagnosis Network for CNS Tumors....
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