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Article

Structural Comparison of the Human G93A Mutant SOD1 to the Wild-type SOD1 Filaments.

Journal of molecular biology - 15 Mar 2026

Baek Yeongjin, Lee Hyojeong, Park Eun-Su, Park Minho, Wee Yurim, Kim Hyunmin, Roh Soung-Hun, Ha Nam-Chul

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease characterized by Cu, Zn-superoxide dismutase (SOD1) misfolding and aggregation, particularly in familial cases. The G93A mutation in SOD1, strongly associated with familial ALS, is widely studied in transgenic mouse models of the disease. In this study, we investigated the filament structure of the G93A mutant SOD1 using...

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Identifiers

PMID: 41565003
DOI: 10.1016/j.jmb.2026.169642

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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