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Article

Innate gene signature distinguishes humoral versus cytotoxic responses to influenza vaccination

7 Mar 2019

Abstract excerpt

BACKGROUND: Systems vaccinology allows cutting-edge analysis of innate biomarkers of vaccine efficacy. We have been exploring novel strategies to shape the adaptive immune response, by targeting innate immune cells through novel immunization routes. METHODS: This randomized phase I/II clinical study (n=60 healthy subjects aged 18-45 years old) used transcriptomic analysis to discover early biomarkers of immune...

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PMID: 30843873
DOI: 10.1172/jci125372

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