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Mitochondrial haplogroups have a better correlation to insulin requirement than nuclear genetic variants for type 2 diabetes mellitus in Taiwanese individuals.

Journal of diabetes investigation - 1 Jan 2022

Shen Feng-Chih, Weng Shao-Wen, Tsai Meng-Han, Su Yu-Jih, Li Sung-Chou, Chang Shun-Jen, Chen Jung-Fu, Chang Yen-Hsiang, Liou Chia-Wei, Lin Tsu-Kung, Chuang Jiin-Haur, Lin Ching-Yi, Wang Pei-Wen

Abstract excerpt

AIMS/INTRODUCTION: Identifying diabetes-susceptible genetic variants will help to provide personalized therapy for the management of type 2 diabetes. Previous studies have reported a genetic risk score (GRS), computed by the sum of nuclear DNA (nDNA) risk alleles, that may predict the future requirement for insulin therapy. Although mitochondrial dysfunction has a close association with insulin resistance (IR),...

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Share to Diabetes Mellitus, Type 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34255930
DOI: 10.1111/jdi.13629
PMCID: PMC8756312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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