Mitochondrial DNA backgrounds might modulate diabetes complications rather than T2DM as a whole.

doi:10.1371/journal.pone.0021029

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Article

Mitochondrial DNA backgrounds might modulate diabetes complications rather than T2DM as a whole.

PloS one - 1 Jan 2011

Achilli Alessandro, Olivieri Anna, Pala Maria, Hooshiar Kashani Baharak, Carossa Valeria, Perego Ugo A, Gandini Francesca, Santoro Aurelia, Battaglia Vincenza, Grugni Viola, Lancioni Hovirag, Sirolla Cristina, Bonfigli Anna Rita, Cormio Antonella, Boemi Massimo, Testa Ivano, Semino Ornella, Ceriello Antonio, Spazzafumo Liana, Gadaleta Maria Nicola, Marra Maurizio, Testa Roberto, Franceschi Claudio, Torroni Antonio

Abstract excerpt

Mitochondrial dysfunction has been implicated in rare and common forms of type 2 diabetes (T2DM). Additionally, rare mitochondrial DNA (mtDNA) mutations have been shown to be causal for T2DM pathogenesis. So far, many studies have investigated the possibility that mtDNA variation might affect the risk of T2DM, however, when found, haplogroup association has been rarely replicated, even in related populations,...

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PMID: 21695278
DOI: 10.1371/journal.pone.0021029
PMCID: PMC3111471

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