Article
Advances in the Immunotherapeutic Potential of Isocitrate Dehydrogenase Mutations in Glioma.
Neuroscience bulletin - 1 Sept 2022
Tang Feng, Pan Zhiyong, Wang Yi, Lan Tian, Wang Mengyue, Li Fengping, Quan Wei, Liu Zhenyuan, Wang Zefen, Li Zhiqiang
Abstract excerpt
Isocitrate dehydrogenase (IDH) is an essential metabolic enzyme in the tricarboxylic acid cycle (TAC). The high mutation frequency of the IDH gene plays a complicated role in gliomas. In addition to affecting gliomas directly, mutations in IDH can also alter their immune microenvironment and can change immune-cell function in direct and indirect ways. IDH mutations mediate immune-cell infiltration and function by...
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