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Article

Telomere dysfunction instigates inflammation in inflammatory bowel disease

12 Jul 2021

Abstract excerpt

Inflammatory bowel disease (IBD) is a chronic inflammatory condition driven by diverse genetic and nongenetic programs that converge to disrupt immune homeostasis in the intestine. We have reported that, in murine intestinal epithelium with telomere dysfunction, DNA damage-induced activation of ataxia-telangiectasia mutated (ATM) results in ATM-mediated phosphorylation and activation of the YAP1 transcriptional...

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PMID: 34253611
DOI: 10.1073/pnas.2024853118

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