Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Telomere dysfunction activates YAP1 to drive tissue inflammation

21 Sept 2020

Abstract excerpt

Germline telomere maintenance defects are associated with an increased incidence of inflammatory diseases in humans, yet whether and how telomere dysfunction causes inflammation are not known. Here, we show that telomere dysfunction drives pATM/c-ABL-mediated activation of the YAP1 transcription factor, up-regulating the major pro-inflammatory factor, pro-IL-18. The colonic microbiome stimulates cytosolic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to IL-33, ST2, and ILC Pathways
Share to Inflammasome and immune disorders
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32958778
DOI: 10.1038/s41467-020-18420-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Telomere dysfunction activates YAP1 to drive tissue inflammationPMID 32958778Read ↗

Telomere dysfunction instigates inflammation in inflammatory bowel diseaseSemantic proximity Read ↗

LncRNA Malat1 represses Th17 effector program by maintaining a critical bivalent super-enhancer and promotes intestinal inflammationSemantic proximity Read ↗

The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1.Semantic proximity Read ↗

Inflammatory Stromal Aging in Ulcerative Colitis and Colitis-Associated CancerSemantic proximity Read ↗

Exploring the Role of YAP1 and TAZ in Pancreatic Acinar Cells and the Therapeutic Potential of VT-104 in Pancreatic InflammationSemantic proximity Read ↗

BMAL1 and YAP cooperate to hijack enhancers and promote inflammation in the aged epidermisSemantic proximity Read ↗

The regulatory feedback of inflammatory signaling and telomere/telomerase complex dysfunction in chronic inflammatory diseasesSemantic proximity Read ↗

Ulcerative Colitis Is a Disease of Accelerated Colon Aging: Evidence From Telomere Attrition and DNA DamageSemantic proximity Read ↗

BMAL1 and YAP Cooperate to hijack enhancers and promote inflammation in the Aged EpidermisSemantic proximity Read ↗

Telomere shortening accelerates tumor initiation in the L2-IL1B mouse model of Barrett esophagus and emerges as a possible biomarkerSemantic proximity Read ↗

The m6A methyltransferase METTL3 modifies Kcnk6 promoting on inflammation associated carcinogenesis is essential for colon homeostasis and defense system through histone lactylation dependent YTHDF2 bindingSemantic proximity Read ↗

Crosstalk Between ALPK1 and STING: A Synergistic Axis in Innate Immune Activation and Human Inflammatory DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.