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Article

A bimodal activation mechanism underlies scorpion toxin-induced pain.

Science advances - 1 Aug 2017

Yang Shilong, Yang Fan, Zhang Bei, Lee Bo Hyun, Li Bowen, Luo Lei, Zheng Jie, Lai Ren

Abstract excerpt

Venomous animals use peptide toxins for hunting and self-defense. To achieve these goals, toxins need to bind to their targets with high affinity due to the small amount that a single bite or sting can deliver. The scorpion toxin BmP01 is linked to sting-induced excruciating pain; however, the reported minimum concentrations for activating TRPV1 channel or inhibiting voltage-gated potassium (Kv) channels (both in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28782041
DOI: 10.1126/sciadv.1700810
PMCID: PMC5540258

Genes

TRPV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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