Article
Mycobacterium tuberculosis complex lineage 5 exhibits high levels of within-lineage genomic diversity and differing gene content compared to the type strain H37Rv.
Microbial genomics - 1 Jul 2021
Sanoussi C N'Dira, Coscolla Mireia, Ofori-Anyinam Boatema, Otchere Isaac Darko, Antonio Martin, Niemann Stefan, Parkhill Julian, Harris Simon, Yeboah-Manu Dorothy, Gagneux Sebastien, Rigouts Leen, Affolabi Dissou, de Jong Bouke C, Meehan Conor J
Abstract excerpt
Pathogens of the Mycobacterium tuberculosis complex (MTBC) are considered to be monomorphic, with little gene content variation between strains. Nevertheless, several genotypic and phenotypic factors separate strains of the different MTBC lineages (L), especially L5 and L6 (traditionally termed Mycobacterium africanum) strains, from each other. However, this genome variability and gene content, especially of L5...
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