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Article

Dimerization of a pathogenic human mitochondrial tRNA.

Nature structural biology - 1 Aug 2002

Wittenhagen Lisa M, Kelley Shana O

Abstract excerpt

Mutations of human mitochondrial transfer RNA (tRNA) are implicated in a variety of multisystemic diseases. The most prevalent pathogenic mitochondrial mutation is the A3243G substitution within the gene for tRNA(Leu(UUR)). Here we describe the pronounced structural change promoted by this mutation. The A3243G mutation induces the formation of a tRNA dimer that strongly self-associates under physiological...

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Source

Identifiers

PMID: 12101407
DOI: 10.1038/nsb820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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