Article
Deep Sequencing to Detect Diversity of Trypanosoma cruzi Infection in Patients Coinfected With Human Immunodeficiency Virus and Chagas Disease.
The Journal of infectious diseases - 18 Jan 2022
Bowman Natalie M, Balasubramanian Sujata, Gilman Robert H, Parobek Christian, Calderon Maritza, Waltmann Andreea, Messenger Louisa A, Sanchez Leny, Bern Caryn, Juliano Jonathan J
Abstract excerpt
Chagas disease, caused by Trypanosoma cruzi, can reactivate and cause severe acute disease in immunocompromised patients such as those infected with human immunodeficiency virus (HIV). We conducted amplicon deep sequencing of a 327-bp fragment of the tcscd5 gene using an Ion Torrent PGM directly from clinical samples from HIV patients with high parasitemia. We describe the within-host diversity, both...
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