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Article

Physiological, genetical and morphological alterations in Mycobacterium avium subsp. paratuberculosis mutants generated with the CRISPRi system.

BMC microbiology - 26 Jan 2026

Lee Jun Ho, Kyung Su Min, Lee Eun-Seo, Xiang Xi-Rui, Park Hyun-Eui, Shin Min-Kyoung, Yoo Han Sang

Abstract excerpt

BACKGROUND: Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of Johne’s disease (JD), a chronic granulomatous enteritis in ruminants. In humans, MAP has been implicated in Crohn’s disease for decades, without conclusive evidence of pathogenicity. Despite the existence of JD’s association with ruminants and humans, the mechanism that links pathogenicity of MAP to resistance to host defense...

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Identifiers

PMID: 41588330
DOI: 10.1186/s12866-026-04743-z
PMCID: PMC12964914

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