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Article

cfSNV: a software tool for the sensitive detection of somatic mutations from cell-free DNA.

Nature protocols - 1 May 2023

Li Shuo, Hu Ran, Small Colin, Kang Ting-Yu, Liu Chun-Chi, Zhou Xianghong Jasmine, Li Wenyuan

Abstract excerpt

Cell-free DNA (cfDNA) in blood, viewed as a surrogate for tumor biopsy, has many clinical applications, including diagnosing cancer, guiding cancer treatment and monitoring treatment response. All these applications depend on an indispensable, yet underdeveloped task: detecting somatic mutations from cfDNA. The task is challenging because of the low tumor fraction in cfDNA. Recently, we developed the...

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Identifiers

PMID: 36849599
DOI: 10.1038/s41596-023-00807-w
PMCID: PMC10411976

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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