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Article

Association between SCN1A polymorphism and carbamazepine responsiveness in epilepsy: A meta-analysis.

Epilepsy research - 1 Oct 2021

Zhang Xuan, Liu Jia, Ye Jing

Abstract excerpt

BACKGROUND: Carbamazepine (CBZ) is one of most used antiepileptic drugs. However, CBZ-resistance is common in patients with epilepsy, and genetic polymorphisms can influence antiepileptic drug responsiveness. The association between the polymorphisms rs3812718 and rs2298771 of theSCN1A gene and risk of resistance to CBZ in epilepsy remains controversial. To further assess the pooled association, we conducted an...

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PMID: 34218210
DOI: 10.1016/j.eplepsyres.2021.106627

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