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Article

Associations between CYP3A4, CYP3A5 and SCN1A polymorphisms and carbamazepine metabolism in epilepsy: A meta-analysis.

Epilepsy research - 1 Jul 2021

Zhao Gui-Xin, Zhang Zheng, Cai Wen-Ke, Shen Ming-Li, Wang Ping, He Gong-Hao

Abstract excerpt

BACKGROUND AND OBJECTIVE: CYP3A4 (rs2242480), CYP3A5 (rs776746) and SCN1A (rs3812718 and rs2298771) gene polymorphisms were previously indicated to be associated with carbamazepine (CBZ) metabolism and resistance in epilepsy. However, previous studies regarding the effects of these polymorphisms still remain controversial. Therefore, we performed a meta-analysis to evaluate whether the four polymorphisms are...

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PMID: 33756436
DOI: 10.1016/j.eplepsyres.2021.106615

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