Article
Association between two functional SNPs of SCN1A gene and efficacy of carbamazepine monotherapy for focal seizures in Chinese Han epileptic patients.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences - 1 May 2014
Wang Ping, Zhou Qiuhong, Sheng Yanghao, Tang Beisha, Liu Zhaoqian, Zhou Boting
Abstract excerpt
OBJECTIVE: To investigate whether single nucleotide polymorphisms (SNPs) of rs2298771 and rs3812718 of the sodium channel α-subunit type 1 (SCN1A) gene affect the efficacy of carbamazepine (CBZ) treatment for seizures in Chinese Han epileptic patients. METHODS: SNP rs2298771 and rs3812718 of the SCN1A gene from 628 patients were genotyped. CBZ monotherapy was administered to the subjects with new-onset partial...
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