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Article

Association between SCN1A polymorphism and carbamazepine-resistant epilepsy.

British journal of clinical pharmacology - 1 Aug 2008

Abe Tomohide, Seo Takayuki, Ishitsu Takateru, Nakagawa Takehiro, Hori Masaharu, Nakagawa Kazuko

Abstract excerpt

AIMS: To establish whether the SCN1A IVS5-91 G > A polymorphism of the SCN1A gene, which encodes the neuronal sodium channel alpha subunit, affects responsiveness to the antiepileptic drugs (AEDS) carbamazepine and/or phenytoin. METHODS: SCN1A IVS5-91 G > A polymorphism was genotyped in 228 Japanese epileptic patients treated with AEDs. The association between AED responsiveness and the polymorphism was estimated...

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Source

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Identifiers

PMID: 18489610
DOI: 10.1111/j.1365-2125.2008.03203.x
PMCID: PMC2492927

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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