Article
Genetic Variation in the Mitochondrial Glycerol-3-Phosphate Acyltransferase Is Associated With Liver Injury.
Hepatology (Baltimore, Md.) - 1 Dec 2021
Hakim Aaron, Moll Matthew, Brancale Joseph, Liu Jiangyuan, Lasky-Su Jessica A, Silverman Edwin K, Vilarinho Silvia, Jiang Z Gordon, Pita-Juárez Yered H, Vlachos Ioannis S, Zhang Xuehong, Åberg Fredrik, Afdhal Nezam H, Hobbs Brian D, Cho Michael H
Abstract excerpt
BACKGROUND AND AIMS: Most of the genetic basis of chronic liver disease remains undiscovered. APPROACH AND RESULTS: To identify genetic loci that modulate the risk of liver injury, we performed genome-wide association studies on circulating levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total bilirubin across 312,671 White British participants in the UK...
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