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Article

Spatial immunoprofiling of the intratumoral and peritumoral tissue of renal cell carcinoma patients.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2021

Brück Oscar, Lee Moon Hee, Turkki Riku, Uski Ilona, Penttilä Patrick, Paavolainen Lassi, Kovanen Panu, Järvinen Petrus, Bono Petri, Pellinen Teijo, Mustjoki Satu, Kreutzman Anna

Abstract excerpt

While the abundance and phenotype of tumor-infiltrating lymphocytes are linked with clinical survival, their spatial coordination and its clinical significance remain unclear. Here, we investigated the immune profile of intratumoral and peritumoral tissue of clear cell renal cell carcinoma patients (n = 64). We trained a cell classifier to detect lymphocytes from hematoxylin and eosin stained tissue slides. Using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34215851
DOI: 10.1038/s41379-021-00864-0
PMCID: PMC8592837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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