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Article

Pro-aging effects of glucose signaling through a G protein-coupled glucose receptor in fission yeast.

PLoS genetics - 1 Mar 2009

Roux Antoine E, Leroux Alexandre, Alaamery Manal A, Hoffman Charles S, Chartrand Pascal, Ferbeyre Gerardo, Rokeach Luis A

Abstract excerpt

Glucose is the preferred carbon and energy source in prokaryotes, unicellular eukaryotes, and metazoans. However, excess of glucose has been associated with several diseases, including diabetes and the less understood process of aging. On the contrary, limiting glucose (i.e., calorie restriction) slows aging and age-related diseases in most species. Understanding the mechanism by which glucose limits life span is...

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Identifiers

PMID: 19266076
DOI: 10.1371/journal.pgen.1000408
PMCID: PMC2646135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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