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Article

Mechanisms of expression and translocation of major fission yeast glucose transporters regulated by CaMKK/phosphatases, nuclear shuttling, and TOR.

Molecular biology of the cell - 15 Jan 2015

Saitoh Shigeaki, Mori Ayaka, Uehara Lisa, Masuda Fumie, Soejima Saeko, Yanagida Mitsuhiro

Abstract excerpt

Hexose transporters are required for cellular glucose uptake; thus they play a pivotal role in glucose homeostasis in multicellular organisms. Using fission yeast, we explored hexose transporter regulation in response to extracellular glucose concentrations. The high-affinity transporter Ght5 is regulated with regard to transcription and localization, much like the human GLUT transporters, which are implicated in...

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PMID: 25411338
DOI: 10.1091/mbc.E14-11-1503
PMCID: PMC4294683

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