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Article

Toward a global analysis of metabolites in regulatory mutants of yeast.

Analytical and bioanalytical chemistry - 1 Nov 2011

Humston Elizabeth M, Dombek Kenneth M, Tu Benjamin P, Young Elton T, Synovec Robert E

Abstract excerpt

The AMP-activated protein kinase in yeast, Snf1, coordinates expression and activity of numerous intracellular signaling and developmental pathways, including those regulating cellular differentiation, response to stress, meiosis, autophagy, and the diauxic transition. Snf1 phosphorylates metabolic enzymes and transcription factors to change cellular physiology and metabolism. Adr1 and Cat8, transcription factors...

Topics

Gas Chromatography-Mass Spectrometry
Gene Expression Regulation, Fungal
Gluconeogenesis
Metabolome
Metabolomics
Mutation
Protein Serine-Threonine Kinases
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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Identifiers

PMID: 21416166
DOI: 10.1007/s00216-011-4800-2
PMCID: PMC3708646

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