Article
Zinc-binding domain mediates pleiotropic functions of Yvh1 in Cryptococcus neoformans.
Journal of microbiology (Seoul, Korea) - 1 Jul 2021
Jin Jae-Hyung, Choi Myung Kyung, Cho Hyun-Soo, Bahn Yong-Sun
Abstract excerpt
Yvh1 is a dual-specificity phosphatase (DUSP) that is evolutionarily conserved in eukaryotes, including yeasts and humans. Yvh1 is involved in the vegetative growth, differentiation, and virulence of animal and plant fungal pathogens. All Yvh1 orthologs have a conserved DUSP catalytic domain at the N-terminus and a zinc-binding (ZB) domain with two zinc fingers (ZFs) at the C-terminus. Although the DUSP domain is...
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