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Article

ATR regulates neuronal activity by modulating presynaptic firing.

Nature communications - 1 Jul 2021

Kirtay Murat, Sell Josefine, Marx Christian, Haselmann Holger, Ceanga Mihai, Zhou Zhong-Wei, Rahmati Vahid, Kirkpatrick Joanna, Buder Katrin, Grigaravicius Paulius, Ori Alessandro, Geis Christian, Wang Zhao-Qi

Abstract excerpt

Ataxia Telangiectasia and Rad3-related (ATR) protein, as a key DNA damage response (DDR) regulator, plays an essential function in response to replication stress and controls cell viability. Hypomorphic mutations of ATR cause the human ATR-Seckel syndrome, characterized by microcephaly and intellectual disability, which however suggests a yet unknown role for ATR in non-dividing cells. Here we show that ATR...

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Identifiers

PMID: 34210973
DOI: 10.1038/s41467-021-24217-2
PMCID: PMC8249387

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