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Chronic Myeloid Leukemia Stem Cells

6 Jun 2008

Abstract excerpt

Although rare, chronic myeloid leukemia (CML) represents an important paradigm for understanding the molecular events leading to malignant transformation of primitive hematopoietic progenitors. CML was the first cancer to be associated with a defined genetic abnormality, BCR-ABL, that is necessary and sufficient for initiating chronic phase disease as well as the first cancer to be treated with molecular targeted...

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PMID: 18539972
DOI: 10.1200/jco.2008.17.5745

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