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Functional Domains and Evolutionary History of the PMEL and GPNMB Family Proteins.

Molecules (Basel, Switzerland) - 9 Jun 2021

Chrystal Paul W, Footz Tim, Hodges Elizabeth D, Jensen Justin A, Walter Michael A, Allison W Ted

Abstract excerpt

The ancient paralogs premelanosome protein (PMEL) and glycoprotein nonmetastatic melanoma protein B (GPNMB) have independently emerged as intriguing disease loci in recent years. Both proteins possess common functional domains and variants that cause a shared spectrum of overlapping phenotypes and disease associations: melanin-based pigmentation, cancer, neurodegenerative disease and glaucoma. Surprisingly, these...

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Identifiers

PMID: 34207849
DOI: 10.3390/molecules26123529
PMCID: PMC8273697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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