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Article

The Double-Edge Sword of Autophagy in Cancer: From Tumor Suppression to Pro-tumor Activity

7 Oct 2020

Abstract excerpt

During tumorigenesis, cancer cells are exposed to a wide variety of intrinsic and extrinsic stresses that challenge homeostasis and growth. Cancer cells display activation of distinct mechanisms for adaptation and growth even in the presence of stress. Autophagy is a catabolic mechanism that aides in the degradation of damaged intracellular material and metabolite recycling. This activity helps meet metabolic...

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PMID: 33117715
DOI: 10.3389/fonc.2020.578418

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