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Analysis of Escherichia coli nicotinate mononucleotide adenylyltransferase mutants in vivo and in vitro.

BMC biochemistry - 9 Sept 2005

Stancek Martin, Schnell Robert, Rydén-Aulin Monica

Abstract excerpt

BACKGROUND: Adenylation of nicotinate mononucleotide to nicotinate adenine dinucleotide is the penultimate step in NAD+ synthesis. In Escherichia coli, the enzyme nicotinate mononucleotide adenylyltransferase is encoded by the nadD gene. We have earlier made an initial characterization in vivo of two mutant enzymes, NadD72 and NadD74. Strains with either mutation have decreased intracellular levels of NAD+,...

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PMID: 16153292
DOI: 10.1186/1471-2091-6-16
PMCID: PMC1249556

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