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Nucleic Acid Sensing by STING Induces an IFN-like Antiviral Response in a Marine Invertebrate

3 May 2024

Abstract excerpt

The cytosolic detection of pathogen-derived nucleic acids has evolved as an essential strategy for host innate immune defense in mammals. One crucial component in this process is the stimulator of IFN genes (STING), which acts as a vital signaling adaptor, connecting the cytosolic detection of DNA by cyclic GMP-AMP (cGAMP) synthase (cGAS) to the downstream type I IFN signaling pathway. However, this process...

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PMID: 38700419
DOI: 10.4049/jimmunol.2300669

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