Article
A CRISPR-based assay for the study of eukaryotic DNA repair onboard the International Space Station.
PloS one - 1 Jan 2021
Stahl-Rommel Sarah, Li David, Sung Michelle, Li Rebecca, Vijayakumar Aarthi, Atabay Kutay Deniz, Bushkin G Guy, Castro Christian L, Foley Kevin D, Copeland D Scott, Castro-Wallace Sarah L, Alvarez Saavedra Ezequiel, Gleason Emily J, Kraves Sebastian
Abstract excerpt
As we explore beyond Earth, astronauts may be at risk for harmful DNA damage caused by ionizing radiation. Double-strand breaks are a type of DNA damage that can be repaired by two major cellular pathways: non-homologous end joining, during which insertions or deletions may be added at the break site, and homologous recombination, in which the DNA sequence often remains unchanged. Previous work suggests that...
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