Article
CCR3 gene overexpression in patients with Down syndrome.
Molecular biology reports - 1 Jun 2021
Salemi Michele, Cannarella Rossella, Marchese Giovanna, Salluzzo Maria Grazia, Ravo Maria, Barone Concetta, Cordella Angela, Caniglia Salvatore, Castiglione Roberto, Ragalmuto Alda, Calogero Aldo E, Romano Corrado
Abstract excerpt
Chromosome 21 trisomy or Down syndrome (DS) is the most common genetic cause of intellectual disability (ID). DS is also associated with hypotonia, muscle weakness, autoimmune diseases, and congenital heart disease. C-C chemokine receptor type 3 (CCR3) plays a role in inflammatory, autoimmune, and neuronal migration mechanisms. The present study aimed to evaluate the expression of the CCR3 gene by NGS and qRT-PCR...
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