Article
A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1).
Genomics - 1 Sept 1997
Gosset P, Ghezala G A, Korn B, Yaspo M L, Poutska A, Lehrach H, Sinet P M, Créau N
Abstract excerpt
The Down syndrome chromosome region-1 (DCR1) on subband q22.2 of chromosome 21 is thought to contain genes contributing to many features of the trisomy 21 phenotype, including dysmorphic features, hypotonia, and psychomotor delay. Isolation, mapping, and sequencing of trapped exons and captured c...
Topics
- Adult
- Amino Acid Sequence
- Animals
- Base Sequence
- Chromosome Mapping
- Chromosomes, Human, Pair 21
- Cloning, Molecular
- Cosmids
- DNA, Complementary
- Down Syndrome
- Exons
- Gene Expression
- Humans
- Molecular Sequence Data
- Open Reading Frames
- Phenotype
- Potassium Channels
- Potassium Channels, Inwardly Rectifying