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Transcriptomic changes upon epoxiconazole exposure in a human stem cell-based model of developmental toxicity

18 Jun 2021

Abstract excerpt

Conazole fungicides such as epoxiconazole are mostly used on cereals of crops to inhibit fungal growth through direct inhibition of sterol 14α-demethylase (CYP51A1). However, this enzyme is highly conserved and in humans it is part of the steroid hormone biosynthesis pathway. Endocrine disrupting effects of epoxiconazole have been shown in rodents and have been substantiated by in vitro data, however, the...

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PMID: 34182286
DOI: 10.1016/j.chemosphere.2021.131225

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