Article
Epigenetic transgenerational actions of endocrine disruptors.
Endocrinology - 1 Jun 2006
Anway Matthew D, Skinner Michael K
Abstract excerpt
Endocrine disruptors have recently been shown to promote an epigenetic transgenerational phenotype involving a number of disease states (e.g. male infertility). The anti-androgenic fungicide vinclozolin was found to act transiently at the time of embryonic sex determination to promote in the F1 generation a spermatogenic cell defect and subfertility in the male. When the animals were allowed to age up to 1 yr, a...
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