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Article

Genetic variation in plant CYP51s confers resistance against voriconazole, a novel inhibitor of brassinosteroid-dependent sterol biosynthesis.

PloS one - 1 Jan 2013

Rozhon Wilfried, Husar Sigrid, Kalaivanan Florian, Khan Mamoona, Idlhammer Markus, Shumilina Daria, Lange Theo, Hoffmann Thomas, Schwab Wilfried, Fujioka Shozo, Poppenberger Brigitte

Abstract excerpt

Brassinosteroids (BRs) are plant steroid hormones with structural similarity to mammalian sex steroids and ecdysteroids from insects. The BRs are synthesized from sterols and are essential regulators of cell division, cell elongation and cell differentiation. In this work we show that voriconazole, an antifungal therapeutic drug used in human and veterinary medicine, severely impairs plant growth by inhibiting...

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Identifiers

PMID: 23335967
DOI: 10.1371/journal.pone.0053650
PMCID: PMC3546049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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