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Mini review - The role of Glucocerebrosidase and Progranulin as possible targets in the treatment of Parkinson's disease.

Revue neurologique - 1 Nov 2021

Rodrigues P S, Kale P P

Abstract excerpt

As per recent reports, there is an association between glucocerebrosidase (Gcase) enzyme and Parkinson's disease (PD). In addition, certain mutations in the Gcase gene (GBA) and the progranulin (PGRN) gene are found to be linked with the imbalance in the levels of Gcase enzyme. This imbalance or decrease or impairment in Gcase activity can lead to Gaucher disease, frontotemporal lobar degeneration (FTLD),...

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Identifiers

PMID: 34175090
DOI: 10.1016/j.neurol.2021.01.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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