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Article

Genetic mutations in adaptive evolution of growth-independent vancomycin-tolerant Staphylococcus aureus.

The Journal of antimicrobial chemotherapy - 11 Oct 2021

Liu Pilong, Hao Zehua, Liu Miaomiao, Niu Mingze, Sun Peng, Yan Shunhua, Zhao Lixiu, Zhao Xin

Abstract excerpt

BACKGROUND: Antibiotic tolerance allows bacteria to overcome antibiotic treatment transiently and potentially accelerates the emergence of resistance. However, our understanding of antibiotic tolerance at the genetic level during adaptive evolution of Staphylococcus aureus remains incomplete. We sought to identify the mutated genes and verify the role of these genes in the formation of vancomycin tolerance in S....

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PMID: 34302174
DOI: 10.1093/jac/dkab260

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