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Adaptive laboratory evolution and independent component analysis disentangle complex vancomycin adaptation trajectories

19 Jul 2022

Abstract excerpt

Human infections with methicillin-resistant Staphylococcus aureus (MRSA) are commonly treated with vancomycin, and strains with decreased susceptibility, designated as vancomycin-intermediate S. aureus (VISA), are associated with treatment failure. Here, we profiled the phenotypic, mutational, and transcriptional landscape of 10 VISA strains adapted by laboratory evolution from one common MRSA ancestor, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35858453
DOI: 10.1073/pnas.2118262119

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