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Article

Epithelial-mesenchymal transitions in development and pathologies.

Current opinion in cell biology - 1 Dec 2003

Thiery Jean Paul

Abstract excerpt

The epithelial-mesenchymal transition (EMT) is a fundamental process governing morphogenesis in multicellular organisms. This process is also reactivated in a variety of diseases including fibrosis and in the progression of carcinoma. The molecular mechanisms of EMT were primarily studied in epithelial cell lines, leading to the discovery of transduction pathways involved in the loss of epithelial cell polarity...

Topics

Animals
Carcinoma
Cell Line
Epithelial Cells
Epithelium
GTP Phosphohydrolases
Humans
Mesoderm
Models, Biological
Morphogenesis
Phenotype
Protein-Tyrosine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Signal Transduction

Transcription, Genetic

Transforming Growth Factor beta

Source

Identifiers

PMID: 14644200
DOI: 10.1016/j.ceb.2003.10.006

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